3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

Autor:	Paul Bauer, Jayvardhan Pandit, Judith L. Treadway, Gayle K. Schulte, Mahmoud N. Mansour, Ing-Kae Wang, George A. Karam, L. D. Mcclure, Anthony Carlo, Dennis E. Danley, David L. Hageman, Stephen W. Wright
Rok vydání:	2003
Předmět:	Models Molecular Indoles Swine Stereochemistry Carboxylic acid Clinical Biochemistry Allosteric regulation Fructose 1 6-bisphosphatase Pharmaceutical Science Regulatory site Crystallography X-Ray Biochemistry Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Humans Enzyme Inhibitors Molecular Biology Indole test chemistry.chemical_classification Dose-Response Relationship Drug biology Organic Chemistry Fructose Adenosine Monophosphate Recombinant Proteins Fructose-Bisphosphatase Rats chemistry Enzyme inhibitor Glycine biology.protein Molecular Medicine Rabbits Propionates Allosteric Site
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:2055-2058
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00310-x
Popis:	3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54f9dc7b1380d82306b818d62517461 https://doi.org/10.1016/s0960-894x(03)00310-x Zobrazit plný text záznamu Full Text from ScienceDirect