Desulfonylation of Indoles and 7-Azaindoles Using Sodium tert-Butoxide
| Autor: | Charlotte Chaulet, Marie-Claude Viaud-Massuard, Joan Basset, Maria-Dolores Pujol, Cécile Croix |
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| Přispěvatelé: | Cambefort, Jeanne, Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Quimica Farmaceutica Lab |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Indole test
3-b]pyridine [CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry Chemistry Sodium Organic Chemistry chemistry.chemical_element sodium tert-butoxide 010402 general chemistry Sodium tert-butoxide [CHIM.ORGA] Chemical Sciences/Organic chemistry 01 natural sciences 0104 chemical sciences N-desulfonylation chemistry.chemical_compound indole sealed tube Organic chemistry 1H-pyrrolo[2 |
| Zdroj: | SYNLETT SYNLETT, Georg Thieme Verlag, 2010, pp.1481-1484 |
| ISSN: | 0936-5214 1437-2096 |
| Popis: | International audience; A mild method for the desulfonylation of N-indoles and N-azaindoles is described. Deprotection is carried out under basic conditions, using sodium tert-butoxide in dioxane. Several functionalized indoles and 7-azaindoles were efficiently deprotected by this method, which is mild enough to be used to deprotect compounds including functions that are known to be sensitive to acidic or basic conditions. |
| Databáze: | OpenAIRE |
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