Functional hepatic flow and Doppler-assessed total hepatic flow in control subjects and in patients with cirrhosis
| Autor: | Donatella Magalotti, Ghigi Gino, Giulio Marchesini, Marco Zoli, Bianchi Giampaolo, Cristina Orlandini, Emilio Pisi, M Grimaldi |
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| Přispěvatelé: | Zoli M., Magalotti D., Giampaolo B., Gino G., Orlandini C., Grimaldi M., Marchesini G., Pisi E. |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Functional hepatic flow Hepatic clearance Gastroenterology Total hepatic flow Clinical investigation Internal medicine medicine Humans Sorbitol In patient D-Sorbitol clearance Aged Cirrhosi Hepatology Echo-Doppler business.industry Arterial blood flow Ultrasonography Doppler Blood flow Middle Aged Control subjects medicine.disease Diuretics Osmotic Intrahepatic shunt Flow (mathematics) Female business Liver Circulation |
| Zdroj: | Journal of hepatology. 23(2) |
| ISSN: | 0168-8278 |
| Popis: | Functional hepatic flow and total hepatic flow were determined by non-invasive techniques in 32 patients with cirrhosis and in 32 paired control subjects. Functional hepatic flow was measured by the hepatic clearance of D-sorbitol, while total hepatic flow was determined by pulsed echo-Doppler, as the sum of portal and hepatic arterial blood flow. Functional hepatic flow was significantly reduced in patients with cirrhosis (927 +/- 314 vs. 1287 +/- 315; p < 0.0001), while total hepatic flow was slightly increased (1511 +/- 540 vs. 1261 +/- 321 in controls; p = 0.028). In control subjects functional hepatic flow significantly correlated with total hepatic flow (r = 0.823; p < 0.001), while no correlation was observed in cirrhosis. Functional hepatic flow and the difference between total hepatic flow and functional hepatic flow significantly correlated with the Child-Pugh score in patients with cirrhosis. The data obtained in control subjects support the measurement of functional hepatic flow and total hepatic flow by non-invasive techniques. The finding that in cirrhosis functional hepatic flow is significantly decreased, while Doppler-assessed total hepatic flow is preserved or even increased, confirms that a relevant part of blood flowing through the liver is diverted by intrahepatic shunts. The simultaneous assessment of these two parameters by non-invasive techniques may be proposed as a reliable tool for the study of functional shunting of cirrhosis. |
| Databáze: | OpenAIRE |
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