Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds

Autor:	Heechol Jeon, Heeyeong Cho, Nam Hyun Jo, Jung-Hyuck Cho, Kyung Ho Yoo, J. H. Choi, Chang-Hyun Oh
Rok vydání:	2007
Předmět:	Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Spectrophotometry Infrared Stereochemistry Microbial Sensitivity Tests Gram-Positive Bacteria Medicinal chemistry Chemical synthesis Pyrrolidine Structure-Activity Relationship chemistry.chemical_compound Gram-Negative Bacteria Spectroscopy Fourier Transform Infrared Drug Discovery Moiety Antibacterial agent Pharmacology chemistry.chemical_classification Organic Chemistry Biological activity General Medicine Oxime Anti-Bacterial Agents Sulfonamide Carbapenems chemistry Indicators and Reagents Spectrophotometry Ultraviolet Antibacterial activity
Zdroj:	European Journal of Medicinal Chemistry. 42:358-364
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2006.10.006
Popis:	The synthesis of a new series of 1β-methylcarbapenems having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound ( IIIc ) having methylaminosulfonamide moiety showed the most potent antibacterial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54c88eb93aeca77638a26fe08ff3fcb https://doi.org/10.1016/j.ejmech.2006.10.006 Zobrazit plný text záznamu Full Text from ScienceDirect