Emerging neurotropic features of SARS-CoV-2
| Autor: | Wei-Ya Tian, Wen-Rong Zhan, Jing Huang, Zhen-Ge Luo, Peng-Ming Zeng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
brain invasion
viruses Neurotropism ACE2 Review Disease AcademicSubjects/SCI01180 medicine.disease_cause Virus Hyposmia Genetics Humans Medicine Molecular Biology Stroke Coronavirus SARS-CoV-2 business.industry Hypogeusia virus diseases Brain COVID-19 Cell Biology General Medicine medicine.disease neurological manifestations Immunology Nervous System Diseases medicine.symptom business Encephalitis |
| Zdroj: | Journal of Molecular Cell Biology |
| ISSN: | 1759-4685 |
| DOI: | 10.1093/jmcb/mjab044 |
| Popis: | The prevailing coronavirus disease-19 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has presented some neurological manifestations including hyposmia, hypogeusia, headache, stroke, encephalitis, Guillain–Barre syndrome, and some neuropsychiatric disorders. Although several cell types in the brain express angiotensin-converting enzyme-2 (ACE2), the main SARS-CoV-2 receptor, and other related proteins, it remains unclear whether the observed neurological manifestations are attributed to virus invasion into the brain or just comorbidities caused by dysregulation of systemic factors. Here, we briefly review the neurological manifestations of SARS-CoV-2, summarize recent evidence for the potential neurotropism of SARS-CoV-2, and discuss the potential mechanisms of COVID-19-associated neurological diseases. |
| Databáze: | OpenAIRE |
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