Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge
| Autor: | Atallah Abbas, Adi Sharabi-Nov, Maayan Rauch, Roee Gutman, Snait Tamir, Mariel Pinsky |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Leptin
0301 basic medicine Physiology Peptide Hormones Ontogeny lcsh:Medicine Biochemistry Energy homeostasis Fats Mice chemistry.chemical_compound Pregnancy Corticosterone Medicine and Health Sciences Morphogenesis lcsh:Science 2. Zero hunger Maternal deprivation Sexual Differentiation Multidisciplinary Stomach Animal Models Lipids Body Fluids Milk Physiological Parameters Experimental Organism Systems Body Composition Female Anatomy Research Article medicine.medical_specialty Mouse Models Weaning Biology Breast milk Research and Analysis Methods Beverages 03 medical and health sciences Model Organisms Internal medicine medicine Animals Nutrition Sexual Dimorphism lcsh:R Body Weight Wild type Biology and Life Sciences Hormones Diet Gastrointestinal Tract 030104 developmental biology Endocrinology chemistry lcsh:Q Digestive System Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 11, p e0188658 (2017) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0188658 |
| Popis: | We investigated whether long-lived weight-reduced αMUPA mice differ from their wild types in postnatal body composition and leptin level, and whether these differences are affected by maternal-borne factors. Newborn αMUPA and wild type mice had similar body weight and composition up to the third postnatal week, after which αMUPA mice maintained lower body weight due to lower fat-free mass. Both strains showed a surge in leptin levels at the second postnatal week, initiating earlier in αMUPA mice, rising higher and lasting longer than in the wild types, mainly in females. Leptin level in dams' serum and breast milk, and in their pup's stomach content were also higher in αMUPA than in the WT during the surge peak. Leptin surge preceded the strain divergence in body weight, and was associated with an age-dependent decrease in the leptin:fat mass ratio-suggesting that postnatal sex and strain differences in leptin ontogeny are strongly influenced by processes independent of fat mass, such as production and secretion, and possibly outside fat tissues. Dam removal elevated corticosterone level in female pups from both strains similarly, yet mitigated the leptin surge only in αMUPA-eliminating the strain differences in leptin levels. Overall, our results indicate that αMUPA's postnatal leptin surge is more pronounced than in the wild type, more sensitive to maternal deprivation, less related to pup's total adiposity, and is associated with a lower post-weaning fat-free mass. These strain-related postnatal differences may be related to αMUPA's higher milk-borne leptin levels. Thus, our results support the use of αMUPA mice in future studies aimed to explore the relationship between maternal (i.e. milk-borne) factors, postnatal leptin levels, and post-weaning body composition and energy homeostasis. |
| Databáze: | OpenAIRE |
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