Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex
| Autor: | Yoshika Fujitani, Hirotaka Kanzaki, Mamoru Ouchida, Yoshihisa Kitamura, Hiromu Kawasaki, Yutaka Gomita, Kouhei Kitagawa, K. Akiyama, Kazuhiko Shibata, Kenji Shimizu, Toshiaki Sendo, Shizue Kimoto |
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| Rok vydání: | 2008 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Imipramine Serotonin Time Factors medicine.drug_class Receptor expression Tricyclic antidepressant Adrenocorticotropic hormone Pharmacology Antidepressive Agents Tricyclic Serotonergic Adrenocorticotropic Hormone Internal medicine Tremor medicine Animals ACTH receptor Receptor Serotonin 5-HT2A RNA Messenger Rats Wistar 5-HT receptor Cerebral Cortex Binding Sites business.industry lcsh:RM1-950 Amphetamines Hydroxyindoleacetic Acid Rats Serotonin Receptor Agonists Up-Regulation Disease Models Animal Endocrinology lcsh:Therapeutics. Pharmacology Molecular Medicine Ketanserin Serotonin Antagonists business medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 106, Iss 1, Pp 100-106 (2008) |
| ISSN: | 1347-8613 |
| Popis: | We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)2receptors and levels of 5-HT2A–receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the binding of [3H]-ketanserin to 5-HT2receptors and the expression of 5-HT2A–receptor mRNA in the frontal cortex. However, it did not alter the concentration of 5-HT or 5-hydroxyindole acetic acid. The effect of chronic ACTH treatment on 5-HT2receptor and 5-HT2A–receptor mRNA levels was not altered by the chronic administration of imipramine. Also, imipramine did not affect the hyperfunction of 5-HT2Areceptors caused by chronic ACTH treatment. These findings suggest that chronic treatment with ACTH acts to increase 5-HT2A– receptor synthesis through increased gene transcription, without modulating presynaptic serotonergic neurotransmission. Keywords:: 5-HT2Areceptor, adrenocorticotropic hormone, wet-dog shake, receptor binding, receptor mRNA |
| Databáze: | OpenAIRE |
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