Phase II Study to Evaluate the Toxicity and Efficacy of Concurrent Cisplatin and Radiation Therapy in the Treatment of Patients with Locally Advanced Squamous Cell Carcinoma of the Cervix
| Autor: | Robert Pearcey, Grant D. MacLean, Jill Nation, Michael Brundage, Himu Lukka, Keith James, J.F. Jeffrey, Gavin Stuart, K. Arthur |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Phases of clinical research Actuarial Analysis Humans Medicine Cervix Pelvis Cisplatin Chemotherapy business.industry Obstetrics and Gynecology Combined Modality Therapy Surgery Survival Rate Clinical trial Radiation therapy medicine.anatomical_structure Oncology Toxicity Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Follow-Up Studies medicine.drug |
| Zdroj: | Gynecologic Oncology. 58:38-41 |
| ISSN: | 0090-8258 |
| DOI: | 10.1006/gyno.1995.1180 |
| Popis: | Sixty patients presenting with poor prognosis squamous cell cancer of the cervix have been studied in a phase II clinical trial. Patients were treated with radiotherapy and concurrent cisplatin chemotherapy every 10 days. Treatment was well tolerated with all patients completing radiotherapy as prescribed. There was one case of grade 4 acute bowel toxicity. Significant late morbidity was acceptable for this group of patients being restricted to two cases (3.3%) of grade 4 toxicity to the bowel. Pelvic control rates of 78% have been observed. There have been no pelvic recurrences after 26 months, although recurrences beyond the pelvis have occurred up to 4 years later. Actuarial 4-year survival is encouraging at 60%. |
| Databáze: | OpenAIRE |
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