Ezetimibe inhibits lymphatic transport of esterified cholesterol but not free cholesterol in thoracic lymph duct-cannulated rats
| Autor: | Bungo Shirouchi, Masao Sato, Aya Shiraishi, Hiroko Tomoyori, Yumiko Furukawa, Katsumi Imaizumi, Yuri Nakamura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Absorption (skin) Permanent thoracic lymph duct cannulation Thoracic duct Catheterization Thoracic Duct Rats Sprague-Dawley chemistry.chemical_compound Ezetimibe Intestinal mucosa Internal medicine medicine Animals Pharmacology (medical) Cholesterol absorption Lipid Transport Lymphatic Vessels Pharmacology Lymphatic esterified cholesterol transport Esterification Cholesterol business.industry Anticholesteremic Agents Biological Transport General Medicine Rats Lymphatic system Endocrinology medicine.anatomical_structure chemistry Azetidines lipids (amino acids peptides and proteins) Lymph Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy. 26(5):427-431 |
| ISSN: | 0920-3206 |
| Popis: | PURPOSE: / Ezetimibe has been shown to inhibit dietary cholesterol absorption in animal models and humans, but studies on lymphatic lipid transport have not yet been performed. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of ezetimibe on lipid transport. / / METHODS: / Rats were fed diets with and without ezetimibe (5.0 mg/kg), and their lymph was collected after feeding to quantify lymphatic lipid levels. Total cholesterol content in the intestinal mucosa was also measured. / / RESULTS: / Rats that consumed ezetimibe had significantly lower lymphatic total cholesterol transport with the reduction of esterified cholesterol transport. According to the calculation based on cholesterol consumption, ezetimibe reduced the total cholesterol lymphatic recovery rate by 54 %. We also determined that ezetimibe significantly reduced the total cholesterol content in the intestinal mucosa. / / CONCLUSION: / This is the first direct evidence that ezetimibe inhibits esterified but not free cholesterol lymphatic transport in thoracic duct-cannulated rats. The results also indicate that ezetimibe is not involved in the lymphatic transport of triacylglycerols, phospholipids, or α-tocopherol. |
| Databáze: | OpenAIRE |
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