Catechins as Tools to Understand the Molecular Basis of Neurodegeneration
| Autor: | Giuseppe Melacini, Rashik Ahmed, Karla Martinez Pomier |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Amyloid
Amyloid beta Pharmaceutical Science Review Computational biology Analytical Chemistry lcsh:QD241-441 03 medical and health sciences α-synuclein 0302 clinical medicine lcsh:Organic chemistry catechin Drug Discovery medicine Humans Alzheimer’s Disease Molecular Targeted Therapy Physical and Theoretical Chemistry 030304 developmental biology 0303 health sciences biology Chemistry Organic Chemistry Neurodegeneration Neurodegenerative Diseases medicine.disease Green tea NMR amyloid beta Neuroprotective Agents Chemistry (miscellaneous) Amyloid aggregation biology.protein Molecular Medicine α synuclein Protein folding EGCG 030217 neurology & neurosurgery |
| Zdroj: | Molecules Molecules, Vol 25, Iss 3571, p 3571 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25163571 |
| Popis: | Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the underlying molecular mechanisms and may offer insight on potential therapeutic solutions. These modulators include green tea catechins, which are potent inhibitors of amyloid aggregation. Although catechins often exhibit poor pharmacokinetic properties and bioavailability, they are still essential tools for identifying the drivers of amyloid aggregation and for developing other aggregation modulators through structural mimicry. As an illustration of such strategies, here we review how catechins have been used to map the toxic surfaces of oligomeric amyloid-like species and develop catechin-based phenolic compounds with enhanced anti-amyloid activity. |
| Databáze: | OpenAIRE |
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