Effect of bacterial vaginosis on the pharmacokinetics of misoprostol in early pregnancy
| Autor: | A. Sioutas, A. Sandström, Christian Fiala, Kristina Gemzell-Danielsson, Horst Schweer, Bernhard Watzer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Cmax Biological Availability Young Adult Pharmacokinetics Pregnancy medicine Humans Prospective Studies Pregnancy Complications Infectious Misoprostol Biotransformation Abortifacient Agents Nonsteroidal Obstetrics business.industry Rehabilitation Area under the curve Obstetrics and Gynecology Abortion Induced Vaginosis Bacterial Mifepristone Hydrogen-Ion Concentration medicine.disease Medical abortion Administration Intravaginal Pregnancy Trimester First Reproductive Medicine Case-Control Studies Female Bacterial vaginosis business medicine.drug |
| Zdroj: | Human Reproduction. 27:388-393 |
| ISSN: | 1460-2350 0268-1161 |
| Popis: | background: Misoprostol has been shown to be an effective agent for cervical ripening and termination of early pregnancy especially when administered vaginally. Our objective was to evaluate whether bacterial vaginosis (BV) affected the pharmacokinetics of vaginally administered misoprostol during early pregnancy. methods: Ten women with BV and 10 healthy women requesting medical abortion up to 9 weeks of pregnancy were administered 200 mg mifepristone followed 24 –48 h later by a single dose of 800 mg misoprostol vaginally. Blood samples were taken before (0 h) and 0.5, 1, 2, 3 and 4 h after misoprostol administration. Misoprostol acid was determined in serum samples using liquid chromatography/tandem mass spectrometry. results: All women with BV had a vaginal pH . 4.7. The mean bioavailability measured as the area under the curve (AUC) and maximum concentration (Cmax) appeared higher in the control than in the BV group (1458.7 versus 878.1 pg h/ml) and (630.7 versus 342.5 pg/ml), respectively, but did not achieve statistical significance and there was no other significant difference in the pharmacokinetics between the two groups. However, if two women with vaginal pH . 4.7 were excluded from the control group the difference in AUC240 (1359 versus 878.1 pg h/ml) reached statistical significance (P ¼ 0.048). conclusions: BV had an effect on pharmacokinetics of vaginally administered misoprostol in early pregnancy. However, the results should be interpreted with caution due to the small sample size and marked individual variations. |
| Databáze: | OpenAIRE |
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