Bronchial fenestration improves expiratory flow in emphysematous human lungs
| Autor: | Bryan F. Meyers, Joel D. Cooper, G. Alexander Patterson, Kimiaki Chino, Henning Lausberg, Patricia D Toeniskoetter |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment Work of breathing Internal medicine Forced Expiratory Volume medicine Lung transplantation Humans Postoperative Period Dynamic hyperinflation Bronchus Lung business.industry Stent respiratory system respiratory tract diseases Surgery medicine.anatomical_structure Pulmonary Emphysema Breathing Cardiology Feasibility Studies Stents Cardiology and Cardiovascular Medicine Airway business |
| Zdroj: | The Annals of thoracic surgery. 75(2) |
| ISSN: | 0003-4975 |
| Popis: | Background The crippling effects of emphysema are due in part to dynamic hyperinflation, resulting in altered respiratory mechanics, an increased work of breathing, and a pervasive sense of dyspnea. Because of the extensive collateral ventilation present in emphysematous lungs, we hypothesize that placement of stents between pulmonary parenchyma and large airways could effectively improve expiratory flow, thus reducing dynamic hyperinflation. Methods Twelve human emphysematous lungs, removed at the time of lung transplantation, were placed in an airtight ventilation chamber with the bronchus attached to a tube traversing the chamber wall, and attached to a pneumotachometer. The chamber was evacuated to −10 cm H 2 O pressure for lung inflation. A forced expiratory maneuver was simulated by rapidly pressurizing the chamber to 20 cm H 2 O, while the expiratory volume was continuously recorded. A flexible bronchoscope was then inserted into the airway and a radiofrequency catheter (Broncus Technologies) was used to create a passage through the wall of three separate segmental bronchi into the adjacent lung parenchyma. An expandable stent, 1.5 cm in length and 3 mm in diameter, was then inserted through each passage. Expiratory volumes were then remeasured as above. In six experiments, two additional stents were then inserted and forced expiratory volumes again determined. Results The forced expiratory volume in 1 second (FEV 1 ) increased from 245 ± 107 mL at baseline to 447 ± 199 mL after placement of three bronchopulmonary stents ( p 1 increased to 666 + 284 mL ( p Conclusions Creation of extra-anatomic bronchopulmonary passages is a potential therapeutic option for emphysematous patients with marked hyperinflation and severe homogeneous pulmonary destruction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|