The artificial intelligence‐assisted cytology diagnostic system in large‐scale cervical cancer screening: A population‐based cohort study of 0.7 million women
Autor: | Sun Xiaorong, Jing Wang, Liang Zhou, Yi Zhang, Fengpin Wu, Pang Baochuan, Linhong Wang, Bojana Turic, Heling Bao, Cao Dehua, Hua Li |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cancer Research Biopsy cervical cancer screening Uterine Cervical Neoplasms Method 0302 clinical medicine Cytology Diagnosis Computer-Assisted Early Detection of Cancer Colposcopy education.field_of_study medicine.diagnostic_test Middle Aged artificial intelligence lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Oncology 030220 oncology & carcinogenesis Female Abnormality Cancer Prevention Cohort study Adult China Cytodiagnosis Population lcsh:RC254-282 03 medical and health sciences Young Adult Deep Learning cytopathology Predictive Value of Tests medicine Humans Radiology Nuclear Medicine and imaging education Aged Vaginal Smears business.industry Reproducibility of Results Odds ratio Uterine Cervical Dysplasia 030104 developmental biology Cytopathology Artificial intelligence Neoplasm Grading business population‐based study |
Zdroj: | Cancer Medicine, Vol 9, Iss 18, Pp 6896-6906 (2020) Cancer Medicine |
ISSN: | 2045-7634 |
Popis: | Background Adequate cytology is limited by insufficient cytologists in a large‐scale cervical cancer screening. We aimed to develop an artificial intelligence (AI)‐assisted cytology system in cervical cancer screening program. Methods We conducted a perspective cohort study within a population‐based cervical cancer screening program for 0.7 million women, using a validated AI‐assisted cytology system. For comparison, cytologists examined all slides classified by AI as abnormal and a randomly selected 10% of normal slides. Each woman with slides classified as abnormal by either AI‐assisted or manual reading was diagnosed by colposcopy and biopsy. The outcomes were histologically confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Results Finally, we recruited 703 103 women, of whom 98 549 were independently screened by AI and manual reading. The overall agreement rate between AI and manual reading was 94.7% (95% confidential interval [CI], 94.5%‐94.8%), and kappa was 0.92 (0.91‐0.92). The detection rates of CIN2+ increased with the severity of cytology abnormality performed by both AI and manual reading (P trend This study aims to assess the role of Artificial Intelligence (AI) in the detection of early cervical cancer in a low resource setting. Our results showed that AI‐assisted cytology could identify most of negative cytology, and showed higher positive predictive value for CIN2 or worse when compared with cytologists. This study indicates that AI‐assisted cytology could be very useful tool as a primary screening method in a large‐scale cervical cancer screening program to improve its effectiveness. |
Databáze: | OpenAIRE |
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