Effects of a desealant formulation, SR-51® and its individual components on the oxidative functions of mitochondria

Autor:	William S. Webster, Michelle Moscova, John K. Pollak, Diana J. Oakes
Rok vydání:	2004
Předmět:	Pharmacology Chromatography Health Toxicology and Mutagenesis Thiophenol General Medicine Oxidative phosphorylation Mitochondrion Toxicology Dimethylacetamide Solvent chemistry.chemical_compound Health problems chemistry Biochemistry Submitochondrial particle EC50
Zdroj:	Environmental Toxicology and Pharmacology. 18:181-184
ISSN:	1382-6689
DOI:	10.1016/j.etap.2004.01.012
Popis:	The Royal Australian Air Force has reported that personnel involved in F-111 fuel tank maintenance were concerned that exposure to a range of chemicals during the period 1977–mid-1990s was the cause of health problems. Particular concern was directed at a desealant chemical mixture known as SR-51 ® . The current study, using in vitro submitochondrial assays, was designed to investigate the relative toxicities of the four components of SR-51 ® (Aromatic 150 solvent (Aro150), dimethylacetamide (DMA), thiophenol (TP) and triethylphosphate (TEP)). Based on the EC50 values, TP and Aro150 were the most toxic components and were markedly more toxic than TEP and DMA. © 2004 Elsevier B.V. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5461a48d517725fa0ee6b96ff2e8167 https://doi.org/10.1016/j.etap.2004.01.012 Zobrazit plný text záznamu Full Text from ScienceDirect