Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo
| Autor: | Keiichi Tasaka, Masahiro Sakata, Tadashi Kimura, Seiji Ogata, Kenjiro Sawada, Ken-ichirou Morishige, Shoko Shimizu, Kae Hashimoto, Masahiro Tahara |
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| Rok vydání: | 2007 |
| Předmět: |
Time Factors
Blotting Western Biophysics Mice Nude Antineoplastic Agents Biology Biochemistry Mice chemistry.chemical_compound In vivo Cell Line Tumor Ovarian carcinoma Lysophosphatidic acid medicine Animals Humans Phosphorylation Molecular Biology Cell Proliferation Ovarian Neoplasms Mice Inbred BALB C Dose-Response Relationship Drug Cell growth Cancer Tyrosine phosphorylation Cell Biology medicine.disease Xenograft Model Antitumor Assays chemistry Cancer cell Disease Progression ras Proteins Cancer research Female Diterpenes Lysophospholipids Mitogen-Activated Protein Kinases Ovarian cancer |
| Zdroj: | Biochemical and Biophysical Research Communications. 356:72-77 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2007.02.102 |
| Popis: | Geranylgeranylacetone (GGA), an isoprenoid compound, is an anti-ulcer drug developed in Japan. In our previous study, GGA was shown to inhibit ovarian cancer invasion by attenuating Rho activation [K. Hashimoto, K. Morishige, K. Sawada, M. Tahara, S. Shimizu, M. Sakata, K. Tasaka, Y. Murata, Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro. Cancer 103 (2005) 1529-1536.]. In the present study, GGA treatment inhibited ovarian cancer progression in vitro and suppressed the tumor growth and ascites in the in vivo ovarian cancer model. In vitro analysis, treatment of cancer cells by GGA resulted in the inhibition of cancer cell proliferation, the inactivation of Ras, and the suppression of tyrosine phosphorylation of mitogen-activated protein kinase (MAPK). In conclusion, this is the first report that GGA inhibited ovarian cancer progression and the anti-tumor effect by GGA is, at least in part, derived not only from the suppression of Rho activation but also Ras-MAPK activation. |
| Databáze: | OpenAIRE |
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