INTENSIVE OBSERVATION OF TOXIC SIDE EFFECTS AFTER SEVERAL-YEAR OF CYCLOSPORIN TREATMENT IN KIDNEY TRANSPLANT PATIENT
| Autor: | Muamera Vrabac-Mujcinagić, Sevleta Avdić, Mensura Ascerić, Sabrija Nukić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
kidney transplant
Adult Graft Rejection Male medicine.medical_specialty concentration Hirsutism Time Factors Urology Diastole Hemorrhage Hyperlipidemias Body weight Kidney transplant Article Tremor medicine Humans Longitudinal Studies Cyclosporine therapy Intensive care medicine Kidney transplantation lcsh:R5-920 Dose-Response Relationship Drug business.industry urogenital system General Medicine toxic side effects Hyperplasia Middle Aged medicine.disease Kidney Transplantation Dose–response relationship Blood pressure Hypertension Cyclosporine Female Kidney Diseases business lcsh:Medicine (General) Immunosuppressive Agents |
| Zdroj: | Bosnian Journal of Basic Medical Sciences, Vol 7, Iss 2 (2007) |
| Popis: | In this work we are going to show results of intensive observation of adverse reactions of cyclosporine therapy during 18 months. The research was applied on 30 patients with kidney transplant. The medium time of kidney transplant survival was 9,7+/-2,3 years, with time span of 6 to 15 years. All the patients were subjects to several years' cyclosporine treatment, which was applied on a daily basis with a dosage of 2 to 5 mg/kg of body weight. The concentration of cyclosporine in blood was measured once a month. The concentration of cyclosporine in blood in 19 patients was in referent values of 122,50 nag/ml up to 280,50 nag/ml of blood. In 4 of the patients the concentration was heightened up to 370 to 538 nag/ml (X=766,37 nag/ml), and in 7 patients cyclosporine was below normal dosage down to 30,78 to 96,30 nag/ml in blood (x=77,12 nag/ml). We noticed these toxic side effects: increased values of systolic and diastolic arterial blood pressure in 5 patients, neurotoxic tremor effects in 4 patients, hyperplasia gingival and hirsute in 1 patient each. |
| Databáze: | OpenAIRE |
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