A multinational European survey on the in-vitro activity of rufloxacin and other comparative antibiotics on respiratory and urinary bacterial pathogens
| Autor: | J. Duval, B. Wiedeman, J. Acar, Richard Wise, Roger Finch, J. Focht, G. Pratts, Adolf Bauernfeind, Ian Phillips, G. Nicoletti, F. Soriano, Gian Carlo Schito |
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| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Klebsiella pneumoniae Rufloxacin Antibiotics Microbial Sensitivity Tests Quinolones Biology medicine.disease_cause Microbiology Haemophilus influenzae chemistry.chemical_compound Anti-Infective Agents Germany Streptococcus pneumoniae medicine Pharmacology (medical) Respiratory Tract Infections Norfloxacin Antibacterial agent Pharmacology Quinolone biology.organism_classification United Kingdom Anti-Bacterial Agents Infectious Diseases Italy chemistry Spain Urinary Tract Infections France Fluoroquinolones medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 38:627-639 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/38.4.627 |
| Popis: | The antibacterial activity of rufloxacin was confirmed against a large number of respiratory and urinary tract pathogens collected in five European countries. In terms of both MIC90 values and percentages of susceptible isolates found, this new quinolone showed useful in-vitro activity against Mycoplasma catarrhalis, Haemophilus influenzae and Klebsiella pneumoniae, with a large proportion of Staphylococcus aureus also covered, while, as expected Streptococcus pneumoniae and Streptococcus pyogenes were not included in its antibacterial spectrum. Rufloxacin was comparable with the other antibiotics against these pathogens with the exception of streptococci. Against these microorganisms, beta-lactams were the most active agents. Against the urinary pathogens the in-vitro activity of rufloxacin is similar to that of norfloxacin although this latter drug is more active in terms of MIC90 values and in percentages of strains inhibited. In many cases more isolates were susceptible to the remaining comparator agents than to rufloxacin. However, there were no significant differences between the numbers of microorganisms inhibited by the various drugs and rufloxacin. The findings of this survey do not seem to modify the general picture which emerged in previous studies and further confirms its useful spectrum in different geographic settings. |
| Databáze: | OpenAIRE |
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