Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4-IgG versus MOG-IgG seropositive cases in the Netherlands
| Autor: | Yu Yi M Wong, E. D. van Pelt, Dörte Hamann, Immy A. Ketelslegers, Rogier Q. Hintzen |
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| Přispěvatelé: | Neurology |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Optic Neuritis Myelitis Transverse Gastroenterology Transverse myelitis Myelin oligodendrocyte glycoprotein 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Optic neuritis Autoantibodies Netherlands Aquaporin 4 Neuromyelitis optica Expanded Disability Status Scale biology business.industry Multiple sclerosis Neuromyelitis Optica Autoantibody Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology Neurology Relative risk Immunoglobulin G Immunology biology.protein Female Myelin-Oligodendrocyte Glycoprotein sense organs Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology, 23(3), 580-587. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1351-5101 |
| Popis: | Background and purpose Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare inflammatory demyelinating disorders of the central nervous system. The identification of specific antibodies directed to aquaporin 4 (AQP4-IgG) led to the distinction from multiple sclerosis. However, up to 25% of the clinically diagnosed NMO patients are seronegative for AQP4-IgG. A subgroup of these patients might be identified by antibodies directed to myelin oligodendrocyte glycoprotein (MOG-IgG). Our objective was to investigate whether the clinical characteristics of these patients differ. Methods Using a cell-based assay, samples of 61 AQP4-IgG seronegative patients and 41 AQP4-IgG seropositive patients with clinically NMOSD were analysed for the presence of MOG-IgG. Clinical characteristics of the AQP4-IgG, MOG-IgG seropositive and double seronegative NMOSD patients were compared. Results Twenty of the 61 AQP4-IgG seronegative patients tested MOG-IgG seropositive (33%). MOG-IgG seropositive patients were more frequently males in contrast to AQP4-IgG seropositive patients (55% vs. 15%, P < 0.01) and Caucasians (90% vs. 63%, P = 0.03). They more frequently presented with coincident optic neuritis and transverse myelitis (40% vs. 12%, P = 0.02) and had a monophasic disease course (70% vs. 29%, P < 0.01). AQP4-IgG seropositive patients were 2.4 times more likely to suffer from relapses compared with MOG-IgG seropositive patients (relative risk 2.4, 95% confidence interval 1.2–4.7). AQP4-IgG seropositive patients had higher Expanded Disability Status Scale levels at last follow-up (P < 0.01). Conclusion Antibodies directed to MOG identify a subgroup of AQP4-IgG seronegative NMO patients with generally a favourable monophasic disease course. |
| Databáze: | OpenAIRE |
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