Oscillating between prone ventilation and ECMO?
| Autor: | Jayshree Lavana, Kiran Shekar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty ARDS High-Frequency Ventilation Acute respiratory distress Prone ventilation Internal medicine Humans Medicine Treatment effect Hypoxia Aged Respiratory Distress Syndrome business.industry Patient data Middle Aged medicine.disease Respiration Artificial Editorial Treatment Outcome Cardiology Female business High frequency oscillatory ventilation |
| Zdroj: | Journal of Thoracic Disease. 10:S4144-S4146 |
| ISSN: | 2077-6624 2072-1439 |
| Popis: | High-frequency oscillatory ventilation (HFOV) is theoretically beneficial for lung protection, but the results of clinical trials are inconsistent, with study-level meta-analyses suggesting no significant effect on mortality.The aim of this individual patient data meta-analysis was to identify acute respiratory distress syndrome (ARDS) patient subgroups with differential outcomes from HFOV.After a comprehensive search for trials, two reviewers independently identified randomized trials comparing HFOV with conventional ventilation for adults with ARDS. Prespecified effect modifiers were tested using multivariable hierarchical logistic regression models, adjusting for important prognostic factors and clustering effects.Data from 1,552 patients in four trials were analyzed, applying uniform definitions for study variables and outcomes. Patients had a mean baseline PaHFOV increases mortality for most patients with ARDS but may improve survival among patients with severe hypoxemia on conventional mechanical ventilation. |
| Databáze: | OpenAIRE |
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