MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM
Autor: | Guo-Xia Zhang, Qing Sun, Nan Jiang, Ping Zhou |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Biophysics Down-Regulation Ataxia Telangiectasia Mutated Proteins Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Stomach Neoplasms Cell Line Tumor microRNA medicine Humans Neoplasm Invasiveness Neoplasm Metastasis Kinase business.industry digestive oral and skin physiology Cancer General Medicine Middle Aged Cadherins medicine.disease digestive system diseases MicroRNAs 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis Cancer cell Cancer research Female Snail Family Transcription Factors miR-203 business |
Zdroj: | Acta Biochimica et Biophysica Sinica. 48:696-703 |
ISSN: | 1672-9145 |
Popis: | Gastric cancer is one of the most common malignancies in the world. A number of miRNAs are aberrantly expressed during the progression of gastric cancer. In this study, we aimed to investigate the role of miR-203 in the invasion and metastasis of gastric cancer and the potential mechanism of the effect of miR-203 on the tumor progression of gastric cancer. Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells, while ataxia telangiectasia mutated kinase (ATM) was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203. Ectopic overexpression of miR-203 inhibited the colony formation, migration, and invasion of gastric cancer cells. In addition, miR-203 overexpression significantly suppressed the protein level of Snail and obviously promoted the protein level of E-cadherin in gastric cancer cells. ATM knockdown phenocopied the effect of miR-203 overexpression. These results suggested that miR-203 suppressed the migration and invasion of gastric cancer through regulating the level of ATM-mediated-Snail and E-cadherin. MiR-203 might be a novel therapeutic strategy for the treatment of gastric cancer. |
Databáze: | OpenAIRE |
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