Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem
| Autor: | Karen A. Waters, Arunnjah Vivekanandarajah, Rita Machaalani |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Nicotine Swine Hippocampus Receptors Nicotinic Developmental Neuroscience Internal medicine medicine Animals Nicotinic Agonists Medulla Acetylcholine receptor business.industry Age Factors Gene Expression Regulation Developmental Sudden infant death syndrome Dorsal motor nucleus Nicotinic agonist Endocrinology Animals Newborn Swine Miniature Female Brainstem business Developmental Biology medicine.drug Brain Stem |
| Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 47 |
| ISSN: | 1873-474X |
| Popis: | Postnatal exposure to cigarette smoke during infancy is associated with increased number of respiratory illnesses, impaired pulmonary function, and the occurrence of Sudden Infant Death Syndrome (SIDS). It is also associated with reduced cognitive functioning and attention deficits in childhood. Nicotine, the major neurotoxic component of cigarette smoke, induces its actions by binding to nicotinic acetylcholine receptors (nAChR). Using a piglet model of postnatal nicotine exposure, we studied the immunohistochemical expression of nAChR subunits α2, α3, α4, α5, α7, α9, β1 and β2 in the brainstem medulla and the hippocampus, given the role of these structures in cardiorespiratory control and cognition, respectively. We compared piglets exposed postnatally to 2mg/kg/day nicotine for 14 days (n=14: 7 males: 7 females) to controls (n=14: 7 males: 7 females). In the hippocampus, decreased expression was seen for α3 in CA1 (p=0.017), α9 in CA1 (p |
| Databáze: | OpenAIRE |
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