Cardiac manifestations of rheumatoid arthritis: a case-control transesophageal echocardiography study in 30 patients

Autor: Bertrand Cormier, Anne-Christine Rat, Marie-Christophe Boissier, Béatrice Barthelemy, Patricia Bianchi-Fior, Claudie Guedes
Přispěvatelé: Rat, Anne-Christine, Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Privé Jacques Cartier [Massy]
Rok vydání: 2001
Předmět:
Aortic valve
Male
medicine.medical_specialty
Heart disease
Heart Diseases
Immunology
MESH: Echocardiography
Transesophageal
Cardiomyopathy
Heart Valve Diseases
Arthritis
Rheumatoid
Pericarditis
Rheumatology
Internal medicine
Mitral valve
Immunology and Allergy
Medicine
Humans
Pharmacology (medical)
Prospective Studies
MESH: Arthritis
Rheumatoid
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Mitral regurgitation
MESH: Humans
MESH: Middle Aged
Tricuspid valve
medicine.diagnostic_test
MESH: Heart Diseases
business.industry
MESH: Heart Valve Diseases
Middle Aged
medicine.disease
MESH: Case-Control Studies
MESH: Prospective Studies
MESH: Male
3. Good health
Surgery
body regions
medicine.anatomical_structure
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Echocardiography
Case-Control Studies
cardiovascular system
Cardiology
MESH: Echocardiography
Female
business
Chest radiograph
MESH: Female
Echocardiography
Transesophageal
Zdroj: Arthritis and Rheumatism
Arthritis and Rheumatism, Wiley, 2001, 45 (2), pp.129-135
ISSN: 0004-3591
1529-0131
Popis: Objectives Current knowledge of the cardiac manifestations of rheumatoid arthritis (RA) stems only from clinical and transthoracic echocardiography (TTE) studies. To determine the incidence and type of heart lesions in RA, we coupled TTE with transesophageal echocardiography (TEE), which is more sensitive and more accurate. Methods Thirty unselected RA patients (26 women and 4 men aged 27 to 84 years, with a mean age of 57.8 ± 15.1 years) free of known progressive heart disease underwent a chest radiograph, an electrocardiogram, laboratory tests, and TTE coupled with TEE. Results were compared with those in age- and sex-matched patients who were free of rheumatic disease and who underwent TEE to investigate a neurologic or cardiologic disorder. Results Mitral regurgitation (MR) was evidenced in 24 cases (80%). Among the controls, only 11 (37%) had MR (P< 0.001). Aortic regurgitation was found in 10 cases (33%), versus 7 controls (not significant—NS). Seven cases (23%) versus only 2 controls (7%) had tricuspid valve abnormalities (NS). Pericarditis was found in 4 cases (13%) and in none of the controls. Eleven cases had evidence of cardiomyopathy (37%) and 12 (40%) had atheroma of the aorta, this last being missed by TTE in 10 patients. Echo-generating nodules were seen on a mitral valve in 2 cases and on an aortic valve in 1. We found no correlations linking cardiac lesions to clinical or laboratory features of RA. Conclusion Our study demonstrated that cardiac involvement, particularly of the mitral valve, is extremely common in RA patients.
Databáze: OpenAIRE
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