Decreasing hyaluronic acid combined with drug-loaded nanoprobes improve the delivery and efficacy of chemotherapeutic drugs for pancreatic cancer
Autor: | Yingfang Fan, Cun-Chuan Wang, Han Deng, Jie Tian, Guan-Hua Lu, Kun-Xiong Guo, Wenting Shang, X.H. Zhu |
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Rok vydání: | 2021 |
Předmět: |
Male
Drug Cancer Research media_common.quotation_subject Cell Hyaluronoglucosaminidase Blood Pressure Drug resistance Extracellular matrix Mice chemistry.chemical_compound Drug Delivery Systems Hyaluronidase Cell Line Tumor Pancreatic cancer Hyaluronic acid Tumor Microenvironment medicine Animals Humans Hyaluronic Acid media_common Mice Inbred BALB C Tumor microenvironment Spectroscopy Near-Infrared Nanotubes Carbon business.industry medicine.disease Pancreatic Neoplasms medicine.anatomical_structure Oncology chemistry Doxorubicin Regional Blood Flow Cancer research business medicine.drug |
Zdroj: | Cancer Letters. 523:1-9 |
ISSN: | 0304-3835 |
Popis: | Pancreatic cancer is one of the common malignant tumors of the digestive system, and its clinical treatment is still very challenging. Most of the pancreatic cancer chemotherapeutic drugs have poor plasma stability, low cell uptake efficiency, and are prone to developing drug resistance and toxic side effects. Besides, pancreatic cancer often has a dense extracellular matrix, which consists of collagens, hyaluronic acid, and other proteoglycans. Among them, hyaluronic acid is a key component of the dense matrix, which results in vascular compression and insufficient perfusion, and hinders the delivery of chemotherapeutic drugs. In this study, we explore using hyaluronidase in tumor-bearing mice to eliminate the hyaluronic acid barrier, to reduce blood vessel compression and reshape the tumor microenvironment. In addition, we evaluate using doxorubicin-loaded nanoprobes to improve the stability and local tumor-killing effect of the drug. The nanoprobes have the characteristics of near-infrared optical imaging, which are used to monitor the tumor size in real-time during the treatment process, and dynamically observe the tumor inhibitory effect. The results show that elimination of the hyaluronic acid barrier combined with the doxorubicin-loaded nanoprobes can greatly increase drug penetration into tumor tissue and improve the effectiveness of chemotherapy drugs. This study provides a novel strategy for the treatment of pancreatic cancer. |
Databáze: | OpenAIRE |
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