Kava feeding in rats does not cause liver injury nor enhance galactosamine-induced hepatitis
| Autor: | Wenyi Zhang, Robert A. DiSilvestro, David DiSilvestro |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
L-Iditol 2-Dehydrogenase Lipid Peroxides medicine.drug_class Galactosamine Pharmacology Toxicology Acetone Bile Acids and Salts Rats Sprague-Dawley Liver Function Tests medicine Animals Glucuronidase Kava Liver injury Hepatitis Dose-Response Relationship Drug Ethanol Lipid peroxide medicine.diagnostic_test Bile acid Plant Extracts Piper methysticum business.industry Hepatotoxin Drug Synergism General Medicine medicine.disease Diet Rats Liver Biochemistry Solvents Chemical and Drug Induced Liver Injury business Liver function tests Biomarkers Food Science |
| Zdroj: | Food and Chemical Toxicology. 45:1293-1300 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2007.01.015 |
| Popis: | Kava, like a number of herbals, has been associated with causing liver damage based on limited evidence. In contrast, the present study found that in rats, 3 mo feedings of two types of kava extracts (an acetone extract and an ethanol extract of the Samoan kava cultivar Ava Laau) at three different doses (31.25, 62.5 and 133 mg/kg diet) produced no liver injury based on serum markers of liver damage (sorbitol dehydrogenase activities, bile acid concentrations, and beta-glucuronidase activities) and serum lipid peroxide readings. In fact, for some measurements and some kava doses, the injury marker readings were below control values. Moreover, for these same parameters, kava feeding did not enhance the effects of the hepatotoxin galacatosamine (500 mg/kg ip); some kava doses even showed modest protection against liver injury. Liver histology analysis showed no signs of kava causing or enhancing liver injury. Thus, this study does not support the concept that kava produces or aggravates liver injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect