Monitoring of Cardiac Troponin I in Patients with Acute Heart Failure
| Autor: | Li Jian Zeng, Yi Ni Chen, Jian Rui Wei, Min Yi Wu |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Cardiac troponin Heart disease Clinical Biochemistry 030209 endocrinology & metabolism macromolecular substances 03 medical and health sciences 0302 clinical medicine Internal medicine Troponin I medicine Humans Myocyte In patient Aged Monitoring Physiologic Aged 80 and over Heart Failure biology business.industry Myocardium General Medicine Middle Aged musculoskeletal system medicine.disease Troponin Heart failure cardiovascular system biology.protein Cardiology Female Creatine kinase business |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 36:433-437 |
| ISSN: | 1758-1001 0004-5632 |
| Popis: | Cardiac troponin I (cTnI) and creatine kinase MB isoenzyme (CK-MB) were measured in the plasma of 37 patients with acute heart failure. Elevated plasma cTnI concentrations were found in 89% of acute heart failure patients ( P < 0·001) compared with a normal population), while plasma CK-MB showed no significant difference ( P = 0·09). During follow-up, serial measurements of cTnI and CK-MB were performed. In acute heart failure patients, improvement of the clinical profile was associated with declining cTnI concentrations, while deterioration of heart function was closely related to increasing cTnI. Plasma CK-MB activities remained within the normal range throughout the observation period. This preliminary study provides evidence of cardiac damage to functionally overloaded myocytes. cTnI may be a sensitive marker both for early detection of myocyte damage and for monitoring of function in patients with acute heart failure. |
| Databáze: | OpenAIRE |
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