Does Plasminogen Activator Inhibitor-1 (PAI-1) Control Trophoblast Invasion? A Study of Fetal and Maternal Tissue in Intrauterine, Tubal and Molar Pregnancies
| Autor: | Lone Sunde, Børge Teisner, Charlotte Floridon, Berit Hølund, Ole Haagen Nielsen, Sten Grove Thomsen, F. Sweep |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Placenta Decidua Parietalis Biology Andrology Decidua Capsularis Pregnancy Development of assays for prognostic factors in oncological endocrinology Internal medicine Plasminogen Activator Inhibitor 1 Decidua medicine Humans Decidual cells Fallopian Tubes reproductive and urinary physiology Obstetrics and Gynecology Trophoblast Decidualization Hydatidiform Mole Immunohistochemistry Trophoblasts Endocrinology medicine.anatomical_structure Reproductive Medicine Ontwikkeling van meetmethodes voor prognostische factoren in de oncologische endocrinologie embryonic structures Chorionic villi Female Pregnancy Tubal Decidua Basalis Chorionic Villi Developmental Biology |
| Zdroj: | Placenta, 21, 754-762 Placenta, 21, 8, pp. 754-762 Floridon, C, Nielsen, O, Hølund, B, Sweep, F, Sunde, L, Thomsen, S G & Teisner, B 2000, ' Does plasminogen activator inhibitor-1 (PAI-1) control trophoblast invasion? A study of fetal and maternal tissue in intrauterine, tubal and molar pregnancies ', Placenta, vol. 21, no. 8, pp. 754-62 . https://doi.org/10.1053/plac.2000.0573 |
| ISSN: | 0143-4004 |
| Popis: | Urokinase plasminogen activator, its receptor and the inhibitor PAI-1 are believed to control proteolysis and remodelling of maternal tissue during trophoblast invasion. This system appears to be strictly regulated in normal intrauterine pregnancies whereas tubal and molar pregnancies seem to be characterized by an uncontrolled excessive placental invasion. This study evaluates subcellular PAI-1 by immunohistochemistry in the villous placenta, in the basal plate and placental bed, and in the decidual compartments of normal, tubal and molar pregnancies. PAI-1 was present in villous syncytiotrophoblasts and co-localized focally with fibrin-type fibrinoid on the surface of the chorionic villi. Basal plate and placental bed extravillous interstitial trophoblasts, as well as vascular trophoblasts, were also PAI-1 positive. In the decidua parietalis, PAI-1 was observed in the cytoplasm of the non-invaded decidual cells. In the decidua basalis comprising the basal plate, PAI-1 was seen to be membrane-associated or confined to the extracellular matrix (ECM) facing the invasive front of anchoring villi. The ECM of decidua capsularis and chorion laeve displayed the most pronounced PAI-1 expression towards the maternal interface. In contrast, the majority of placental bed decidual cells adjacent to the interstitial and vascular trophoblasts were PAI-1 negative. Only a few stromal cells distant from the implantation site were PAI-1 positive in the tubal pregnancies and decidualization was not present. Likewise, excessive decidual necrosis and fibrinoid deposition devoid of PAI-1 was a common finding in complete molar pregnancies. These results suggest that PAI-1 defines specific extravillous invasive trophoblasts within the maternal decidua. Moreover, maternal cellular lack of PAI-1 in tubal pregnancies and excessive decidual necrosis in molar pregnancies indicate an uncontrolled placental invasion. The present data indicate that trophoblast invasion is primarily regulated by signals from decidual cells. |
| Databáze: | OpenAIRE |
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