Daytime sleepiness predicts inflammation and ambulatory blood pressure in sleep apnoea
| Autor: | Ann E. Rogers, Vicki S. Hertzberg, John Cox, Brittany Butts, Arshed A. Quyyumi, Nancy A. Collop, Victoria M. Pak, Sandra B. Dunbar |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Mean arterial pressure Ambulatory blood pressure business.industry Epworth Sleepiness Scale lcsh:R lcsh:Medicine Adipokine Inflammation Original Articles 030204 cardiovascular system & hematology Sleep in non-human animals 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Smoking status medicine.symptom Sleep business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | ERJ Open Research, Vol 6, Iss 4 (2020) ERJ Open Research article-version (VoR) Version of Record |
| ISSN: | 2312-0541 |
| DOI: | 10.1183/23120541.00310-2019 |
| Popis: | Introduction Sleepiness in obstructive sleep apnoea is associated with cardiovascular risk; however, the biological mechanisms are not known. This study explored whether those with subjective sleepiness have increased plasma tumour necrosis factor-related protein 1 (C1qTNF1), a novel adipose-derived hormone (adipokine), and 24-h ambulatory blood pressure (ABP) compared to those without sleepiness in newly diagnosed, treatment-naïve participants with obstructive sleep apnoea. Methods Overall, 94 participants were included in the analysis. Participants completed the Epworth Sleepiness Scale (ESS), 24-h ABP was monitored, and plasma C1qTNF1 was measured. Sleepy participants were defined as ESS≥10 and nonsleepy as ESS Excessive sleepiness experienced by treatment-naïve patients with obstructive sleep apnoea is associated with inflammation, higher daily systolic ambulatory blood pressure and higher 24 h mean arterial pressure https://bit.ly/3goeqGD |
| Databáze: | OpenAIRE |
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