Isolation and structure of a novel peptide inhibitor of HIV-1 integrase from marine polychaetes
| Autor: | L. A. Elyakova, Yu. Yu. Agapkina, S. I. Vantseva, N. I. Khoroshilova, B. V. Vaskovsky |
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| Rok vydání: | 2011 |
| Předmět: |
Homoserine
HIV Infections Peptide HIV Integrase Biochemistry Marine worm Mass Spectrometry chemistry.chemical_compound Residue (chemistry) Animals Humans Amino Acid Sequence HIV Integrase Inhibitors Peptide sequence chemistry.chemical_classification Chromatography biology Edman degradation Organic Chemistry Polychaeta Peptide Fragments Integrase Amino acid chemistry HIV-1 biology.protein |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 37:207-216 |
| ISSN: | 1608-330X 1068-1620 |
| DOI: | 10.1134/s1068162010061019 |
| Popis: | A homogeneous peptide with a mass of 683 Da which inhibits HIV-1 integrase with IC50 3 × 10−5 M was separated from aqueous extracts of a marine worm Eunicidae sp. by multistage chromatography purification. The Asp-Leu-Hse-His-Ala-Gln structure was proposed for this peptide according to amino acid analysis, automated amino acid Edman sequences, and TLC with witness homoserine and MS/MS fragmentation. The proposed structure is the first example of a natural peptide containing an amino acid homoserine residue. |
| Databáze: | OpenAIRE |
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