Clinical Characteristics and Adverse Clinical Outcomes of Invasive Haemophilus influenzae Serotype a Cases—United States, 2011–2015
| Autor: | Tasha Poissant, Sara E. Oliver, Karen Edge, Tara Scheuer, Amy Blain, Lori Triden, Catherine H Bozio, William Schaffner, Elizabeth C. Briere, Monica M. Farley, Salina Torres, Lee H. Harrison |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Haemophilus Infections Population Bacteremia Serogroup law.invention law Internal medicine Epidemiology medicine Humans Child education Aged Haemophilus Vaccines education.field_of_study business.industry Incidence Incidence (epidemiology) Medical record Infant Middle Aged medicine.disease Haemophilus influenzae Intensive care unit United States Pneumonia Infectious Diseases Child Preschool business Meningitis |
| Zdroj: | Clinical Infectious Diseases. 73:e3670-e3676 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Incidence of invasive disease due to Haemophilus influenzae serotype a (Hia) increased an average of 13% annually from 2002 through 2015. We describe clinical characteristics and adverse clinical outcomes of US invasive Hia cases detected through multistate surveillance during 2011–2015. Methods Medical record data were abstracted for cases reported in 8 jurisdictions conducting active population- and laboratory-based surveillance for invasive Hia disease across the United States. Isolates from sterile sites were serotyped using real-time polymerase chain reaction. Adverse clinical outcomes were defined as any possible complication of meningitis, bacteremic pneumonia, or bacteremia (including hearing loss and developmental delay, but excluding death) and were assessed at hospital discharge and one-year post-disease onset. Results During 2011–2015, 190 Hia cases were reported to the 8 participating sites; 169 (88.9%) had data abstracted. Many patients were aged Conclusions Hia infection can cause severe disease that requires hospitalization and may also cause short- and long-term adverse clinical outcomes, especially among children. Novel vaccines could prevent morbidity and mortality. |
| Databáze: | OpenAIRE |
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