Effect of Hyperprolactinemia in Male Patients Consulting for Sexual Dysfunction
| Autor: | Luisa Petrone, Giovanni Corona, Gianni Forti, Giancarlo Balercia, Edoardo Mannucci, Francesco Lotti, Mario Maggi, Alessandra D. Fisher, Valdo Ricca |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism Comorbidity Severity of Illness Index Cohort Studies Endocrinology Erectile Dysfunction Risk Factors Internal medicine Severity of illness medicine Humans Testosterone Aged Proportional Hazards Models Hazard ratio Testosterone (patch) Luteinizing Hormone Middle Aged medicine.disease Prolactin Causality Hyperprolactinemia Psychiatry and Mental health Sexual desire Sexual dysfunction Erectile dysfunction Reproductive Medicine Gynecomastia Follicle Stimulating Hormone medicine.symptom Psychology |
| Zdroj: | The Journal of Sexual Medicine. 4:1485-1493 |
| ISSN: | 1743-6095 |
| Popis: | Introduction The physiological role of prolactin (PRL) in male sexual function has not been completely clarified. Aim The aim of this study is the assessment of clinical features and of conditions associated with hyperprolactinemia in male patients consulting for sexual dysfunction. Methods A consecutive series of 2,146 (mean age 52.2 ± 12.8 years) male patients with sexual dysfunction was studied. Main Outcome Measures Several hormonal and biochemical parameters were studied along with validated structured interviews (ANDROTEST and the Structured Interview on Erectile Dysfunction [SIEDY]). Mild hyperprolactinemia (MHPRL; PRL levels of 420–735 mU/L or 20–35 ng/mL) and severe hyperprolactinemia (SHPRL, PRL levels >735 mU/L, 35 ng/mL) were considered. Results MHPRL and SHPRL were found in 69 (3.3%) and in 32 (1.5%) patients, respectively. Mean age and the prevalence of gynecomastia were similar in the two groups and in subjects with normal prolactin values. MHPRL was not confirmed in almost one-half of the patients after repetitive venous sampling. Hyperprolactinemia was associated with the current use of antidepressants, antipsychotic drugs, and benzamides. SHPRL was also associated with hypoactive sexual desire (HSD), elevated thyrotropin (TSH), and hypogonadism. The association between HSD and SHPRL was confirmed after adjustment for testosterone and TSH levels, and use of psychotropic drugs (hazard ratio [HR] = 8.60[3.85–19.23]; P Conclusions Our data indicate that SHPRL, but not MHPRL, is a relevant determinant of HSD. Gynecomastia does not help in recognizing hyperprolactinemic subjects, while the use of psychotropic medications and HSD are possible markers of disease. In the case of MHPRL, repetitive venous sampling is strongly encouraged. Corona G, Mannucci E, Fisher AD, Lotti F, Ricca V, Balercia G, Petrone L, Forti G, and Maggi M. Effect of hyperprolactinemia in male patients consulting for sexual dysfunction. |
| Databáze: | OpenAIRE |
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