Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
| Autor: | Niklas J. Koehl, Alexandra-Roxana Ilie, Georgia Tsakiridou, Lida Kalantzi, Brendan T. Griffin, Sandra Jankovic, Martin Kuentz, René Holm, Christoph Saal, Felix Ditzinger, Daniel J. Price, Anita Nair, Kristof Kimpe |
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| Jazyk: | angličtina |
| Předmět: |
Computer science
Chemistry Pharmaceutical Pharmaceutical Science Administration Oral 030226 pharmacology & pharmacy Excipients 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Drug Development Quantitative assessment Humans Solubility Particle Size Pharmacology Water Lipids Calculation methods Hildebrand solubility parameter Water soluble Drug development Pharmaceutical Preparations 030220 oncology & carcinogenesis Drug delivery Solvents Pharmaceutics Biochemical engineering |
| Zdroj: | Journal of Pharmacy and Pharmacology |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/jphp.12948 |
| Popis: | Objectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water-soluble drugs. Key findings An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid-based delivery, solid dispersions and nano- or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug. Summary In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early-stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour-intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations. |
| Databáze: | OpenAIRE |
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