HPLC and GC–MS–based metabolic profiles and in vivo anticonvulsant, sedative, and antinociceptive potentials of truffles Tirmania nivea and Tirmania pinoyi hydromethanolic extracts in mice

Autor:	Mona E. Aboutabl, Waill A. Elkhateeb, Marwa A. Masoud, Ghoson M. Daba, Ahmed H. Afifi, Rehab A. Hussein
Rok vydání:	2022
Předmět:	Pharmacology Analgesics Plant Extracts Clinical Biochemistry General Medicine Biochemistry Gas Chromatography-Mass Spectrometry Analytical Chemistry Mice Drug Discovery Metabolome Animals Hypnotics and Sedatives Anticonvulsants Molecular Biology Chromatography High Pressure Liquid
Zdroj:	Biomedical Chromatography. 36
ISSN:	1099-0801 0269-3879
DOI:	10.1002/bmc.5481
Popis:	GC-MS and HPLC analyses of the hydromethanolic extracts of the truffles Tirmania nivea (TN) and Tirmania pinoyi (TP) revealed the presence of 18 metabolites and 11 polyphenols, respectively. In vivo, TP extract protected against subcutaneous pentylenetetrazole (scPTZ) and maximal electric shock (MES)-induced convulsions faster than TN extract. TP extract (100 and 300 mg/kg) showed 100% protection and longer duration than TN extract in the scPTZ test. Similarly, at 300 mg/kg, TP demonstrated a quicker start (75%) and longer duration of action (100%) than TN in MES test. In the scPTZ test, ED
Databáze:	OpenAIRE
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