Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis
| Autor: | Ming Heng Wu, Chang Ta Chiou, Shyun Yeu Liu, Wen Chang Wang, Wei Lun Hwang, Tzu Hao Chang, Chi Hua Chang, Jung Wu Yang, Kuen Haur Lee, Wei Fan Chiang, Ji Dung Luo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty DNA Copy Number Variations Oral Submucous Fibrosis Risk Assessment Gastroenterology Verrucous hyperplasia Malignant transformation Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine SNP Copy-number variation Survival rate Aged Aged 80 and over Hyperplasia business.industry Follow up studies Middle Aged medicine.disease stomatognathic diseases 030104 developmental biology Otorhinolaryngology Oral submucous fibrosis Dysplasia 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Mouth Neoplasms business Follow-Up Studies |
| Zdroj: | Head & Neck. 40:1046-1056 |
| ISSN: | 1043-3074 |
| Popis: | Background Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single-nucleotide polymorphism (SNP) array. Results The 5-year disease-free and cancer-free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1, and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high-risk factors of patients with oral verrucous hyperplasia. The 5-copy number variation-associated genes could be used for early diagnosis and predicting the prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text