Effects of neuronal drebrin on actin dynamics
| Autor: | Elena E. Grintsevich |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gene isoform
Regulator Biology Biochemistry Interactome Microtubules 03 medical and health sciences 0302 clinical medicine Microtubule Alzheimer Disease Cell Movement Animals Humans 030212 general & internal medicine Cytoskeleton Actin 030304 developmental biology Neurons 0303 health sciences Neuronal Plasticity Neuropeptides Actin cytoskeleton Actins Actin Cytoskeleton Synaptic plasticity Neuroscience |
| Zdroj: | Biochemical Society transactions. 49(2) |
| ISSN: | 1470-8752 |
| Popis: | Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark of multiple neurodegenerative disorders such as Alzheimer's disease. Despite its established importance in health and disease, we still have a lot to learn about drebrin's interactome and its effects on cytoskeletal dynamics. This review aims to summarize the recently reported novel effects of drebrin on actin and its regulators. Here I will also reflect on the most recent progress made in understanding of the role of drebrin isoforms and posttranslational modifications on its functionality. |
| Databáze: | OpenAIRE |
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