Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
| Autor: | Ovgu Aydin, Sebnem Batur, Nil Comunoglu, Zeynep Ecem Kain, Emine Deniz Gözen, Nuray Kepil |
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| Přispěvatelé: | İÜC, Cerrahpaşa Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Larynx squamous cell carcinoma Histology Focus Section: Novel Therapies Cell Pathology and Forensic Medicine head and neck 03 medical and health sciences 0302 clinical medicine lcsh:Pathology Medicine Programmed death ligand 1 Head and neck Original Research larynx business.industry Ligand (biochemistry) stomatognathic diseases 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis immunohistochemistry Cancer research Immunohistochemistry business lcsh:RB1-214 Programmed death |
| Zdroj: | Clinical Pathology Clinical Pathology, Vol 13 (2020) |
| ISSN: | 2632-010X |
| Popis: | Aim: We aimed to show the immunohistochemical expression of programmed death ligand 1 (PD-L1) in laryngeal squamous cell carcinomas (SCCs). Materials and methods: The study includes 52 laryngeal SCC cases that underwent surgical resection. Immunohistochemical staining of PD-L1 (Clone 22C3) was applied to the sections obtained from paraffin blocks. Combined Positive Score (CPS) was evaluated as described in manuals. Tumor Proportion Score (TPS) was assessed by the percentage of positive tumor cells which were designated as positive if ⩾1% of the tumor cells showed membranous staining. Results: There were 35 cases (67.3%) having CPS < 1 and 17 cases (32.7%) having CPS ⩾ 1. There was no relationship between CPS, TPS, and the clinicopathological data. Conclusion: Further studies with a large number of advanced-stage cases are needed. © The Author(s) 2020. Istanbul Üniversitesi The authors are grateful to Bugra Taygun Gulle (MD: Department of Public Health, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey), for his help in statistical analysis. The author(s) received no financial support for the research, authorship, and/or publication of this article. |
| Databáze: | OpenAIRE |
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