Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis
| Autor: | Shinji Shimada, Yuumi Nakamura, Kayoko Ishimaru, Noriko Ando, Atsuhito Nakao, Ko Okumura, Hideoki Ogawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Immunology Circadian clock CLOCK Proteins chemical and pharmacologic phenomena Basophil Immunoglobulin E medicine.disease_cause Mice Young Adult Allergen Internal medicine Circadian Clocks medicine Immunology and Allergy Animals Humans Circadian rhythm Pyrophosphatases allergic rhinitis biology Phosphoric Diester Hydrolases Rhinitis Allergic Seasonal hemic and immune systems Period Circadian Proteins Allergens Middle Aged the circadian clock Basophils CLOCK Endocrinology medicine.anatomical_structure Gene Expression Regulation Mutation biology.protein Pollen IgE Brief Communications |
| Zdroj: | Allergy |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | It remains poorly understood how symptoms in allergic rhinitis are most severe during overnight or early in the morning. The circadian clock consisting of a network of several ‘clock genes’ including Clock drives daily rhythms in physiology. This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time-of-day-dependent variation associated with temporal variations in canonical circadian clock gene expression. We also found that bone-marrow-derived basophils (BM basophils) generated from wild-type mice exhibited a time-of-day-dependent variation in IgE-mediated IL-4 and histamine production, which was not observed in BM basophils generated from Clock-mutated mice. Therefore, allergen-specific basophil reactivity shows daily variations depending on the circadian clock activity in basophils, which could partly explain temporal symptomatic variations in allergic rhinitis. Additionally, circadian variations in CD203c expression should be considered for interpretation of this biomarker in clinical research. |
| Databáze: | OpenAIRE |
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