Downsizing Chemotherapy for Initially Unresectable Locally Advanced Biliary Tract Cancer Patients Treated with Gemcitabine Plus Cisplatin Combination Therapy Followed by Radical Surgery
| Autor: | Hideyuki Yoshitomi, Masayuki Ohtsuka, Yukio Nakatani, Tsukasa Takayashiki, Takashi Kishimoto, Hiroaki Shimizu, Eri Nakadai, Hiroyuki Yoshidome, Katsunori Furukawa, Atsushi Kato, Masaru Miyazaki |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Combination therapy medicine.medical_treatment Deoxycytidine Postoperative Complications Surgical oncology Antineoplastic Combined Chemotherapy Protocols medicine Humans Radical surgery Survival rate Aged Neoplasm Staging Aged 80 and over Cisplatin Chemotherapy business.industry Combination chemotherapy Middle Aged Prognosis Combined Modality Therapy Gemcitabine Surgery Survival Rate Biliary Tract Neoplasms Oncology Case-Control Studies Female business Follow-Up Studies medicine.drug |
| Zdroj: | Annals of Surgical Oncology. 22:1093-1099 |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | We have treated patients with initially unresectable locally advanced biliary tract cancer (BTC) by administering gemcitabine and have found that surgical resection became feasible in some downsized patients. The aim of this study was to investigate the usefulness of downsizing combination chemotherapy using gemcitabine plus cisplatin to treat initially unresectable locally advanced BTC. The subjects of the study were 150 consecutive patients who were treated for BTC between October 2011 and April 2014. Downsizing chemotherapy was carried out for 39 patients (26.0 %) whose lesions were unresectable because of locally advanced BTC. Reduction in tumor size with downsizing chemotherapy was seen in 18 patients, and surgical resection was performed in 10 of 39 patients (25.6 %). Median survival time in patients with surgical resection following downsizing chemotherapy and those with chemotherapy alone was 17.9 and 12.4 months, respectively (p = 0.0378). According to the historical comparison between gemcitabine and gemcitabine plus cisplatin chemotherapy, there is no significant difference in overall survival. However, there was a significant difference for the pathologic response rate (≥Grade III) to be higher in patients with gemcitabine plus cisplatin chemotherapy compared with gemcitabine monotherapy. Preoperative downsizing chemotherapy with gemcitabine plus cisplatin provides longer survival by the conversion to the surgical resection in patients with initially unresectable locally advanced BTC. It may have the potential for disease eradication as a new multidisciplinary approach for initially unresectable locally advanced BTC. |
| Databáze: | OpenAIRE |
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