Bioavailability of lemon verbena (Aloysia triphylla) polyphenols in rats: impact of colonic inflammation
| Autor: | Catherine Felgines, Odile Texier, Didier Fraisse, Catherine Besson, Marie-Paule Vasson |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Centre de Recherche en Nutrition Humaine |
| Rok vydání: | 2014 |
| Předmět: |
Male
Colon dietary polyphenols antioxidant activity Medicine (miscellaneous) Biological Availability in-vivo Intestinal absorption Antioxidants Beverages Herbal tea chemistry.chemical_compound Feces Verbascoside intestinal inflammation Caffeic acid Animals rat Lemon verbena polyphenols Rats Wistar Chromatography High Pressure Liquid Analysis of Variance Nutrition and Dietetics Aloysia biology Traditional medicine Dextran Sulfate food and beverages Polyphenols Verbena Colonic inflammation biology.organism_classification Inflammatory Bowel Diseases Diosmetin 3. Good health Rats Disease Models Animal chemistry Intestinal Absorption bioavailability [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Luteolin Lemon verbena |
| Zdroj: | British Journal of Nutrition British Journal of Nutrition, Cambridge University Press (CUP), 2014, 111 (10), pp.1773-1781. ⟨10.1017/s0007114514000026⟩ British Journal of Nutrition, 2014, 111 (10), pp.1773-1781. ⟨10.1017/s0007114514000026⟩ |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114514000026⟩ |
| Popis: | Lemon verbena (Aloysia triphylla) infusion, a widely consumed herbal tea, contains significant amounts of polyphenols such as flavone diglucuronides and phenylpropanoid glycosides (mainly verbascoside). We have recently shown that lemon verbena infusion offers beneficial effects against dextran sodium sulphate (DSS)-induced colonic inflammation in rats. The present study aimed to evaluate the bioavailability and intestinal absorption of polyphenols derived from lemon verbena infusion in both healthy and colitic rats. For this purpose, lemon verbena infusion was given to rats ad libitum for 14 d, and then 4 % DSS was added to the infusion for 7 d. Before and after DSS administration, 24 h urinary excretion of polyphenols was determined. Flavones were excreted in the urine as conjugated aglycones, and their excretion was not significantly altered by colonic inflammation. Only trace amounts of verbascoside were excreted in the urine, but various metabolites (hydroxycinnamic acids) were detected. The urinary excretion of hydroxycinnamic acids, particularly that of caffeic acid, increased after DSS administration (Pin situ intestinal perfusion model. Intestinal absorption of verbascoside and flavone diglucuronides did not significantly differ between the healthy and colitic rats. Collectively, these results show that intestinal absorption and urinary excretion of lemon verbena flavone diglucuronides were not altered by colonic inflammation, but that urinary excretion of hydroxycinnamic acids derived from verbascoside was affected in a colitic situation. |
| Databáze: | OpenAIRE |
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