Dependence receptors: from basic research to drug development
| Autor: | Patrick Mehlen, Dale E. Bredesen |
|---|---|
| Přispěvatelé: | Equipe 1, Centre de Recherche en Cancérologie de Lyon ( CRCL ), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Biological and Medical Informatics [San Francisco] ( BMI ), University of California [San Francisco] ( UCSF ), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biological and Medical Informatics [San Francisco] (BMI), University of California [San Francisco] (UCSF), University of California-University of California |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
MESH : Drug Design
Angiogenesis MESH: Low Back Pain MESH : Prospective Studies MESH : Aged MESH : Receptors Cell Surface Apoptosis MESH : Analysis of Variance Dependence receptor MESH: Pain Measurement MESH : Models Biological Pharmacology MESH: Drug Design Ligands medicine.disease_cause Biochemistry [ SDV.CAN ] Life Sciences [q-bio]/Cancer 0302 clinical medicine MESH : Chronic Disease Basic research MESH: Ligands MESH: Double-Blind Method MESH : Pain Measurement MESH : Female Receptor MESH: Physical Therapy Modalities MESH: Treatment Outcome MESH: Receptors Cell Surface MESH: Aged 0303 health sciences MESH : Ligands MESH: Middle Aged Neurodegeneration MESH: Disability Evaluation MESH : Questionnaires MESH : Adult MESH: Patient Compliance MESH: Interviews as Topic Drug development MESH : Motivation Caspases 030220 oncology & carcinogenesis MESH: Cell Adhesion Molecules Netrin Receptors MESH : Male MESH: Motivation Receptors Cell Surface [SDV.CAN]Life Sciences [q-bio]/Cancer MESH : Disability Evaluation MESH : Treatment Outcome Biology Models Biological MESH : Patient Compliance MESH : Cell Adhesion Molecules 03 medical and health sciences MESH: Analysis of Variance MESH : Adolescent medicine Humans MESH : Double-Blind Method MESH : Middle Aged Molecular Biology 030304 developmental biology MESH: Adolescent MESH: Caspases MESH: Humans MESH: Questionnaires MESH: Apoptosis MESH: Chronic Disease MESH : Humans MESH: Models Biological MESH: Adult Cell Biology medicine.disease MESH: Male MESH: Prospective Studies MESH : Low Back Pain MESH : Physical Therapy Modalities Drug Design MESH : Interviews as Topic MESH : Caspases Carcinogenesis Cell Adhesion Molecules Neuroscience MESH: Female Function (biology) MESH : Apoptosis |
| Zdroj: | Science Signaling Science Signaling, American Association for the Advancement of Science, 2011, 4 (157), pp.mr2. 〈10.1126/scisignal.2001521〉 Science Signaling, American Association for the Advancement of Science, 2011, 4 (157), pp.mr2. ⟨10.1126/scisignal.2001521⟩ |
| ISSN: | 1937-9145 |
| DOI: | 10.1126/scisignal.2001521〉 |
| Popis: | International audience; The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012. |
| Databáze: | OpenAIRE |
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