Comment on 'Evaluation of Antiviral Therapy Performed after Curative Therapy in Patients with HBV-Related Hepatocellular Carcinoma: An Updated Meta-Analysis'
| Autor: | Xue-Mei You, Le-Qun Li, Bang-De Xiang, Jian-Hong Zhong, Han-Yue Mo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment medicine.disease_cause Antiviral Agents 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Overall survival Humans In patient lcsh:RC799-869 Letter to the Editor Hepatitis B virus Hepatology business.industry Incidence (epidemiology) Liver Neoplasms Gastroenterology Antiviral therapy General Medicine medicine.disease digestive system diseases Surgery 030220 oncology & carcinogenesis Meta-analysis Hepatocellular carcinoma 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology business Adjuvant |
| Zdroj: | Canadian Journal of Gastroenterology and Hepatology, Vol 2016 (2016) Canadian Journal of Gastroenterology & Hepatology |
| ISSN: | 2291-2797 2291-2789 |
| Popis: | We read with interest the updated meta-analysis by Yuan et al. [1] which investigated the role of nucleos(t)ide analog (NA) therapy for patients with hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) after surgery. Even after curative resection or ablation, the incidence of HCC recurrence is very high [2]. However, no adjuvant and/or postoperative therapies with definite efficacy to prevent HCC recurrence are recommended by official guidelines. HBV is the main cause of HCC in Asia. In this point, Yuan and coworkers [1] performed an interesting and important updated meta-analysis in order to determine whether antiviral therapy with NA can prevent HCC recurrence and improve patients' survival after surgery. Their meta-analysis showed that NA therapy significantly reduced 1- and 3-year recurrence and significantly improved 1-, 3-, and 5-year overall survival and disease-free survival. We feel that some of these results may need to be treated with caution. And we would like to propose several important issues raised in this meta-analysis. |
| Databáze: | OpenAIRE |
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