Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes
| Autor: | Arumugam Sathya, Perumal Siddhuraju |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Aspartate transaminase Pharmacology Toxicology Diabetes Mellitus Experimental Rats Sprague-Dawley Glibenclamide chemistry.chemical_compound Alloxan medicine Animals Hypoglycemic Agents Aspartate Aminotransferases Acetaminophen Liver injury chemistry.chemical_classification Glutathione Peroxidase biology Plant Extracts Superoxide Dismutase Glutathione peroxidase Acacia Alanine Transaminase Bilirubin General Medicine Alkaline Phosphatase Catalase medicine.disease Glutathione Rats Cholesterol Diabetes Mellitus Type 2 Liver Alanine transaminase chemistry Biochemistry Hepatoprotection Creatinine Plant Bark biology.protein lipids (amino acids peptides and proteins) Liver function Chemical and Drug Induced Liver Injury Biomarkers Food Science medicine.drug |
| Zdroj: | Food and Chemical Toxicology. 56:162-170 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2013.02.031 |
| Popis: | The present study is designed to decipher a clinical evidence and biochemical support for hepatoprotective and antidiabetic efficacy of Acacia auriculiformis by its bark and empty pods. Animal models with paracetamol intoxicated liver injury and alloxan induced diabetes were used in a 7 and 14 days trial respectively. The interventions were tested at 200 and 400 mg/kg b.w. for bark extract; 100 and 200 mg/kg b.w. for empty pod extract. Both interventions restored the liver function markers (alanine transaminase: ALT, aspartate transaminase: AST, alkaline phosphatase: ALP, total bilirubin and total protein) and hepatic antioxidants (superoxide dismutase: SOD, catalase: CAT, reduced glutathione: GSH and glutathione peroxidase: GPx) to the normal levels than elevated levels noticed on paracetamol control at P |
| Databáze: | OpenAIRE |
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