Aminophylline increases respiratory muscle activity during hypercapnia in humans
| Autor: | Masanori, Yokoba, Masato, Katagiri, Tsuyoshi, Ichikawa, Akira, Takakura, Naohito, Ishii, Yoshifumi, Kurosaki, Yuya, Yamada, Tomoaki, Tsukushi, Noriyuki, Masuda, Paul A, Easton, Yasuto, Nishii, Yasumasa, Okada, Tadashi, Abe |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.drug_class Intercostal Muscles Hypercapnia Young Adult Bronchodilator Respiratory muscle Tidal Volume Medicine Humans Pharmacology (medical) Theophylline Tidal volume business.industry Electromyography Biochemistry (medical) Carbon Dioxide Aminophylline Respiratory Muscles respiratory tract diseases Bronchodilator Agents Anesthesia Breathing medicine.symptom business Respiratory minute volume medicine.drug Muscle Contraction |
| Zdroj: | Pulmonary pharmacologytherapeutics. 30 |
| ISSN: | 1522-9629 |
| Popis: | Background Theophylline is an old drug traditionally used as a bronchodilator, although it was recently shown to possess anti-inflammatory properties, enhance the actions of corticosteroid actions, and stimulate the respiratory neuronal network. Theophylline has been recognized as an important drug for not only asthma but also corticosteroid-insensitive chronic obstructive pulmonary disease (COPD). To clarify the role of theophylline in hypercapnic ventilatory responses in humans, we analyzed the effects of aminophylline administered at the usual clinical therapeutic doses on ventilation and augmentation of respiratory muscle contractility in room air and under 3 conditions of hypercapnia. Study design We performed electromyography (EMG) of the parasternal intercostal muscle (PARA) and transversus abdominis muscle (TA) in 7 healthy subjects and recorded both ventilatory parameters and EMG data in room air and under 3 conditions of hypercapnia before (control) and during aminophylline administration. Results Before aminophylline administration (control), hypercapnic stimulation elicited ventilatory augmentation in a hypercapnia intensity-dependent manner. Ventilatory parameters (tidal volume, frequency of respiration, and minute ventilation) showed significant increases from lower PaCO 2 levels during aminophylline administration when compared with the corresponding values before aminophylline administration. EMG activity of both PARA and TA increased significantly at each level of hypercapnia, and those augmentations were shown from lower PaCO 2 levels during aminophylline administration. Conclusion Aminophylline administered at the usual clinical therapeutic dose increases ventilation and EMG activity of both inspiratory and expiratory muscles during hypercapnia in healthy humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect