Sympathetic influence on ventricular compliance
| Autor: | Bernell Coleman, Aldo A. Luisada, Marva C. Worthen, Donald M. McCANON, John E. Kallal |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Left Ventricular Systolic Pressure
medicine.medical_specialty Sympathetic Nervous System Cardiac Volume Heart Ventricles Stellate Ganglion Diastole Blood Pressure Cisterna magna Veratrine Dogs Internal medicine Medicine Animals Blood Transfusion Sympathectomy Whole blood Injections Intraventricular business.industry Heart Myocardial Contraction Sympathetic stimulation Compliance (physiology) Preload medicine.anatomical_structure Ventricle Anesthesia Cardiology Cardiology and Cardiovascular Medicine business Compliance |
| Zdroj: | Japanese heart journal. 17(2) |
| ISSN: | 0021-4868 |
| Popis: | Intracisternal injections of veratrine in the anesthetized dog were used to study the effects of extreme sympathetic stimulation on left ventricular diastolic compliance. The results obtained were compared with those seen during volume expansion with whole blood, and after removal of both stellate ganglia. The injection of veratrine into the cisterna magna caused an increase in left ventricular end-diastolic pressure (LVEDP) which was considerably larger than that which occurred in left ventricular end-diastolic circumferential (LVEDC) segment length suggesting a reduction in diastolic compliance. There were also increases in left ventricular systolic pressure (LVSP) as well as its first derivative (LV dp/dt). Bilateral stellectomy during the veratrine response abruptly reduced LVEDP with a lesser decrease in LVEDC. Thus, the left ventricular compliance change was reversed. Both LVSP and LV dp/dt were decreased by stellectomy but remained above control levels. During transfusion, the pressure-length curve of the ventricle was located down-ward and to the right in comparison with the curve observed with intracisternal veratrine. |
| Databáze: | OpenAIRE |
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