Ten-year outcome of early childhood traumatic brain injury: Diffusion tensor imaging of the ventral striatum in relation to executive functioning

Autor: Mary E. Aitken, Elisabeth A. Wilde, Zili David Chu, Harvey S. Levin, Linda Ewing-Cobbs, Jessica Faber, Samantha H. Mullins, Gerri Hanten, Ragini Yallampalli, Xiansheng Li, Jill V. Hunter, Marianne Macleod, Linda J. Noble-Haeusslein
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Adolescent
Traumatic brain injury
Statistics as Topic
Neuroscience (miscellaneous)
Neuropsychological Tests
050105 experimental psychology
White matter
Executive Function
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Neuroimaging
Brain Injuries
Traumatic
Image Processing
Computer-Assisted
Developmental and Educational Psychology
medicine
Humans
Verbal fluency test
0501 psychology and cognitive sciences
Longitudinal Studies
Early childhood
Child
Psychiatry
Trauma Severity Indices
Verbal Behavior
05 social sciences
Ventral striatum
Cognition
medicine.disease
White Matter
medicine.anatomical_structure
nervous system
Ventral Striatum
Anisotropy
Female
Neurology (clinical)
Cognition Disorders
Psychology
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Brain Injury. 30:1635-1641
ISSN: 1362-301X
0269-9052
DOI: 10.1080/02699052.2016.1199910
Popis: The long-term effects of TBI on verbal fluency and related structures, as well as the relation between cognition and structural integrity, were evaluated. It was hypothesized that the group with TBI would evidence poorer performance on cognitive measures and a decrease in structural integrity.Between a paediatric group with TBI and a group of typically-developing children, the long-term effects of traumatic brain injury were investigated in relation to both structural integrity and cognition. Common metrics for diffusion tensor imaging (DTI) were used as indicators of white matter integrity.Using DTI, this study examined ventral striatum (VS) integrity in 21 patients aged 10-18 years sustaining moderate-to-severe traumatic brain injury (TBI) 5-15 years earlier and 16 demographically comparable subjects. All participants completed Delis-Kaplan Executive Functioning System (D-KEFS) sub-tests.The group with TBI exhibited lower fractional anisotropy (FA) and executive functioning performance and higher apparent diffusion coefficient (ADC). DTI metrics correlated with D-KEFS performance (right VS FA with Inhibition errors, right VS ADC with Letter Fluency, left VS FA and ADC with Category Switching).TBI affects VS integrity, even in a chronic phase, and may contribute to executive functioning deficits.
Databáze: OpenAIRE
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