Effect of head group orientation on phospholipid assembly
| Autor: | Jayashree Saha, Tanay Paul |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Ions
0301 basic medicine Work (thermodynamics) 010304 chemical physics Bilayer Lipid Bilayers Phospholipid Biological membrane Molecular Dynamics Simulation 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Molecular dynamics 030104 developmental biology chemistry Lamellar phase Phase (matter) 0103 physical sciences Biophysics Head (vessel) lipids (amino acids peptides and proteins) Phospholipids |
| Zdroj: | Physical Review E. 95 |
| ISSN: | 2470-0053 2470-0045 |
| DOI: | 10.1103/physreve.95.062703 |
| Popis: | The relationship between bilayer stability and lipid head group orientation is reported. In this work, molecular-dynamics simulations are performed to analyze the structure-property relationship of lipid biomembranes, taking into account coarse-grained model lipid interactions. The work explains the molecular scale mechanism of the phase behavior of lipid systems due to ion-lipid or anesthetic-lipid interactions, where reorientations of dipoles play a key role in modifying lipid phases and thereby alter biomembrane function. Our study demonstrates that simple dipolar reorientation is indeed sufficient in tuning a bilayer to a randomly flipped nonbilayer lamellar phase. This study may be used to assess the impact of changes in lipid phase characteristics on biomembrane structure due to the presence of anesthetics and ions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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