Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy

Autor: Marco Arosio, Manlio Sgarzi, Dario Alimonti, C. Foresti, Riccardo Riva, Barbara Frigeni, Nicola Rifino, Giorgia Camera, Annapaola Callegaro, Bruno Censori, Martina Viganò, Simonetta Gerevini, Stefano Quadri, Emanuela Agazzi, Marcella Vedovello, Tania Partziguian, Benedetta Storti, Virginio Bonito, Maria Cristina Servalli, Marta Zaffira Conti, Maria Grimoldi, Maria Sessa, Elisabetta Venturelli, Sara La Gioia
Přispěvatelé: Rifino, N, Censori, B, Agazzi, E, Alimonti, D, Bonito, V, Camera, G, Conti, M, Foresti, C, Frigeni, B, Gerevini, S, Grimoldi, M, La Gioia, S, Partziguian, T, Quadri, S, Riva, R, Servalli, M, Sgarzi, M, Storti, B, Vedovello, M, Venturelli, E, Viganò, M, Callegaro, A, Arosio, M, Sessa, M
Rok vydání: 2020
Předmět:
Zdroj: Journal of Neurology
ISSN: 1432-1459
0340-5354
Popis: Objectives: Evidences from either small series or spontaneous reporting are accumulating that SARS-CoV-2 involves the Nervous Systems. The aim of this study is to provide an extensive overview on the major neurological complications in a large cohort of COVID-19 patients. Methods: Retrospective, observational analysis on all COVID-19 patients admitted from February 23rd to April 30th, 2020 to ASST Papa Giovanni XXIII, Bergamo, Italy for whom a neurological consultation/neurophysiological assessment/neuroradiologic investigation was requested. Each identified neurologic complication was then classified into main neurologic categories. Results: Of 1760 COVID-19 patients, 137 presented neurologic manifestations that manifested after COVID-19 symptoms in 98 pts and was the presenting symptom in 39. Neurological manifestations were classified as: (a) cerebrovascular disease [53 pts (38.7%)] including 37 ischemic and 11 haemorrhagic strokes, 4 transient ischemic attacks, 1 cerebral venous thrombosis; (b) peripheral nervous system diseases [31 (22.6%)] including 17 Guillain–Barrè syndromes; (c) altered mental status [49 (35.8%)] including one necrotizing encephalitis and 2 cases with RT-PCR detection of SARS-Cov-2 RNA in CSF; (d) miscellaneous disorders, among whom 2 patients with myelopathy associated with Ab anti-SARS-CoV-2 in CSF. Patients with peripheral nervous system involvement had more frequently severe ARDS compared to patients with cerebrovascular disease (87.1% vs 42%; difference = 45.1% 95% CI 42.0–48.2; χ2= 14.306; p < 0.0002) and with altered mental status (87.1% vs 55.6%; difference = 31.5% 95% CI 27.5–37.5%; χ2= 7.055; p < 0.01). Conclusion: This study confirms that involvement of nervous system is common in SARS-CoV-2 infection and offers clinicians useful information for prevention and prompt identification in order to set the adequate therapeutic strategies.
Databáze: OpenAIRE
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