VEGF serum concentration and irreversible bronchoconstriction in adult asthmatics
| Autor: | Urszula Gładysz, Krzysztof Gomułka, Jerzy Liebhart, W Medrala |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A 030213 general clinical medicine medicine.medical_specialty VEGF receptors Bronchoconstriction Medicine (miscellaneous) General Biochemistry Genetics and Molecular Biology Neovascularization Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Pharmacology (medical) Genetics (clinical) Asthma biology business.industry Vascular Endothelial Growth Factors Middle Aged medicine.disease Vascular endothelial growth factor Endocrinology chemistry Case-Control Studies Reviews and References (medical) biology.protein Biomarker (medicine) medicine.symptom Airway business |
| Zdroj: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 28(6) |
| ISSN: | 1899-5276 |
| Popis: | Background Vascular endothelial growth factor (VEGF) is an angiogenic, heparin-binding glycoprotein playing an important role in the pathogenesis of many diseases and disorders, including asthma. It has been reported that increased VEGF serum concentration is a biomarker of neovascularization, which could suggest that higher VEGF expression may be relevant to asthmatics with airway remodeling and irreversible bronchoconstriction. Objectives The aim of this study was to assess the possible association between VEGF serum concentration and irreversible bronchoconstriction in adult patients with a diagnosis of asthma. Material and methods This study involved 82 adult patients with asthma (42 persons with and 40 persons without irreversible bronchoconstriction) and 40 healthy adult controls. Vascular endothelial growth factor serum concentration was analyzed using enzyme-linked immunosorbent assay (ELISA). Results Vascular endothelial growth factor serum concentration in patients with asthma was higher than in healthy controls (p = 0.0131), particularly in those from the subgroup of irreversible bronchoconstriction (p = 0.0133). The rising tendency was confirmed using the Kruskal–Wallis rank sum test that showed a significant difference (p = 0.0374) in VEGF values among the 3 groups examined: healthy controls (Me = 246.6 pg/mL), asthmatics with reversible bronchoconstriction (Me = 288.6 pg/mL) and asthmatics with irreversible bronchoconstriction (Me = 340.6 pg/mL). However, the direct comparison between the 2 asthmatics groups (reversible vs irreversible bronchoconstriction) did not show a statistically significant difference (p = 0.5521). Conclusions Increased VEGF serum concentration is characteristic of patients with asthma, especially those with irreversible bronchoconstriction. |
| Databáze: | OpenAIRE |
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