Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study

Autor: Marit Dahl Solbu, Anne Elise Eggen, Henrik Schirmer, Svetlana N. Zykova, Bjørn Odvar Eriksen, Kirsti Ytrehus, Jon Viljar Norvik, Trond Jenssen
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Cross-sectional study
Epidemiology
030204 cardiovascular system & hematology
Left ventricular hypertrophy
Ventricular Function
Left
0302 clinical medicine
Risk Factors
Cross-sectional
Medicine
Prospective Studies
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771
Aged
80 and over
Ventricular Remodeling
Norway
Incidence
Middle Aged
Prognosis
Cardiovascular disease
Echocardiography
Doppler
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774
Survival Rate
Cardiology
Diastolic dysfunction
Female
Adiponectin
Cardiology and Cardiovascular Medicine
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774
Research Article
medicine.medical_specialty
Heart Ventricles
Diastole
Heart failure
Risk Assessment
03 medical and health sciences
Sex Factors
Internal medicine
Humans
Women
Ventricular remodeling
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771
Aged
Cardiac remodeling
Heart Failure
Diastolic
business.industry
Stroke Volume
Odds ratio
medicine.disease
HFpEF
030104 developmental biology
Endocrinology
Cross-Sectional Studies
Heart failure with preserved ejection fraction
business
Biomarkers
Zdroj: BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Source at https://doi.org/10.1186/s12872-017-0509-2 Background: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. Methods: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomi al regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest. Results: Decreased adiponectin was associated with higher odds of average tissue Doppler e ’ < 9 in women (odds ratio [OR] 1.17 per 1 μ g/mL adiponectin decrease, 95% confidence interval [CI] 1.04 – 1.30), but not in men (p for interaction with sex 0.04). Women, but not men, had higher odds of E/e ’ ratio ≥ 8 with lower adiponectin (OR 1.12 per 1 μ g/mL adiponectin decrease, 95% CI 1.02 – 1.24, p for interaction with sex 0.04). Adiponectin in the lower sex-specific tertile was associated with increased odds of concentric left ventricular hypertrophy in women (OR 2.44, 95% CI 1.03 – 5.77), but with decreased odds in men (OR 0.32, 95% CI 0.11 – 0.88, p for interaction with sex 0.002), and decreased odds of eccentric hypertrophy in men only (OR 0.53, 95% CI 0.33 – 0.88, p for interaction with sex 0.02). Adiponectin in the lower sex-specific tertile was associated with moderately enlarged left atria in women only (OR 1.43, 95% CI 1.01 – 2.03, p for interaction with sex 0.04). Finally, adiponectin had a non-linear relationship with left ventricular mass in women only, with exponentially increasing left ventricular mass with lower adiponectin levels (p for interaction with sex 0.01). Conclusions: Low adiponectin was associated with higher odds of indices of diastolic dysfunction in women, but lower odds of indices of diastolic dysfunction in men. Lower adiponectin was associated with increased left ventricular mass in women only.
Databáze: OpenAIRE
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