Antibiotic-induced immediate type hypersensitivity is a risk factor for positive allergy skin tests for neuromuscular blocking agents
| Autor: | Mihaela Cocis, Cristina Petrisor, Nadia Gherman, Natalia Hagău |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Hypersensitivity Immediate Male Allergy Population Drug allergy Cross Reactions Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Risk Factors 030202 anesthesiology Neuromuscular blocking agent Humans Immunology and Allergy Medicine General anaesthesia Risk factor Rocuronium education Prospective cohort study Skin Tests education.field_of_study business.industry Antibiotic General Medicine medicine.disease Anti-Bacterial Agents 030228 respiratory system Case-Control Studies Anesthesia Latent sensitization Female Neuromuscular Blocking Agents lcsh:RC581-607 business Anaphylaxis medicine.drug |
| Zdroj: | Allergology International, Vol 65, Iss 1, Pp 52-55 (2016) |
| ISSN: | 1323-8930 |
| DOI: | 10.1016/j.alit.2015.07.007 |
| Popis: | Background Skin tests for neuromuscular blocking agents (NMBAs) are not currently recommended for the general population undergoing general anaesthesia. In a previous study we have reported a high incidence of positive allergy tests for NMBAs in patients with a positive history of non-anaesthetic drug allergy, a larger prospective study being needed to confirm those preliminary results. The objective of this study was to compare the skin tests results for patients with a positive history of antibiotic-induced immediate type hypersensitivity reactions to those of controls without drug allergies. Methods Ninety eight patients with previous antibiotic hypersensitivity and 72 controls were prospectively included. Skin tests were performed for atracurium, pancuronium, rocuronium, and suxamethonium. Results We found 65 positive skin tests from the 392 tests performed in patients with a positive history of antibiotic hypersensitivity (1 6.58%) and 23 positive skin tests from the 288 performed in controls (7.98%), the two incidences showing significant statistical difference ( p = 0.0011). The relative risk for having a positive skin test for NMBAs for patients versus controls was 1.77 (1.15–2.76). For atracurium, skin tests were more often positive in patients with a positive history of antibiotic hypersensitivity versus controls ( p = 0.02). For pancuronium, rocuronium and suxamethonium the statistical difference was not attained ( p -values 0.08 for pancuronium, 0.23 for rocuronium, and 0.26 for suxamethonium). Conclusions Patients with a positive history of antibiotic hypersensitivity seem to have a higher incidence of positive skin tests for NMBAs. They might represent a group at higher risk for developing intraoperative anaphylaxis compared to the general population. |
| Databáze: | OpenAIRE |
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