Early-onset gastric cancer: Learning lessons from the young
| Autor: | A.N. Milne, G.J.A. Offerhaus |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Environmental Carcinogen
Helicobacter pylori infection medicine.medical_specialty biology business.industry digestive oral and skin physiology Gastroenterology Cancer Helicobacter pylori biology.organism_classification medicine.disease Bioinformatics Phenotype digestive system diseases Editorial Oncology Older patients Internal medicine Journal Article medicine Gastric carcinogenesis business Early onset |
| Zdroj: | World Journal of Gastrointestinal Oncology, 2(2), 59. Baishideng Publishing Group |
| ISSN: | 1948-5204 |
| Popis: | There is by no means a clear-cut pattern of mutations contributing to gastric cancers, and gastric cancer research can be hampered by the diversity of factors that can induce gastric cancer, such as Helicobacter pylori infection, diet, ageing and other environmental factors. Tumours are unquestionably riddled with genetic changes yet we are faced with an unsolvable puzzle with respect to a temporal relationship. It is postulated that inherited genetic factors may be more important in early-onset gastric cancer (EOGC) than in gastric cancers found in older patients as they have less exposure to environmental carcinogens. EOGC, therefore, could provide a key to unravelling the genetic changes in gastric carcinogenesis. Gastric cancers occurring in young patients provide an ideal background on which to try and uncover the initiating stages of gastric carcinogenesis. This review summarizes the literature regarding EOGC and also presents evidence that these cancers have a unique molecular-genetic phenotype, distinct from conventional gastric cancer. |
| Databáze: | OpenAIRE |
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